It was when working under Professor Jürg Tschopp that she became hooked on the biology of inflammasomes – inflammation-generating molecular machines that trigger immune cells to respond to an infection or injury.She is unravelling the secrets of these protein complexes. Zeis, T., Allaman, I., Gentner, M., Schroder, K., Tschopp, J., Magistretti, P. J. and Schaeren-Wiemers, N. (2015).
Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. Professor Kate Schroder heads the Inflammasome Laboratory and is Director of the Centre for Inflammation and Disease Research at the Institute for Molecular Bioscience (IMB), University of Queensland, as an NHMRC RD Wright Biomedical Fellow. The IMB Inflammasome Laboratory, which Kate heads, investigates the molecular mechanisms governing inflammasome activity and caspase activation, the cellular mediators of inflammasome-dependent inflammation, and mechanisms of inflammasome inhibition by cellular pathways and small molecule inhibitors. Coll, Rebecca C., Robertson, Avril A. Schroder, Kate, Lichtinger, Monika, Irvine, Katharine M., Brion, Kristian, Trieu, Angela, Ross, Ian L., Ravasi, Timothy, Stacey, Katryn J., Rehli, Michael, Hume, David A. and Sweet, Matthew J. Boucher, Dave, Chan, Amy, Ross, Connie and Schroder, Kate (2018).
Rebsamen, Manuele, Heinz, Leonhard X., Meylan, Etienne, Michallet, Marie-Cecile, Schroder, Kate, Hofmann, Kay, Vazquez, Jessica, Benedict, Chris A. and Tschopp, Jurg (2009). B. and Schroder, Kate (2019). (2016).
Inflammasome signaling and regulation of interleukin-1 family cytokinesMCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibitionNoncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular trapsInterleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretionCaspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activityNLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseasesThe Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella ChallengeConservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophagesNLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?The NLRP3 inflammasome: a sensor for metabolic danger?Interferon-gamma: an overview of signals, mechanisms and functionsInflammasome signaling and regulation of interleukin-1 family cytokinesMCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibitionNoncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular trapsInterleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretionCaspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activityNLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseasesThe Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella ChallengeConservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophagesNLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?The NLRP3 inflammasome: a sensor for metabolic danger?Interferon-gamma: an overview of signals, mechanisms and functionsQuantifying caspase-1 activity in murine macrophagesAssessment of inflammasome formation by flow cytometryThe impact of CAGE data on understanding macrophage transcriptional biologyThe impact of CAGE data on the understanding of macrophage transcriptional biologyLipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophagesDesign, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probeThe rOX‐stars of inflammation: links between the inflammasome and mitochondrial meltdownThe microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteinsNeutrophil-derived S100A8/A9 amplify granulopoiesis following myocardial infarctionInflammasome signaling and regulation of interleukin-1 family cytokinesNew insights into inflammasome signalling and function during inflammationInhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammationLack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytesMCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibitionVariation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3-dependent vs. -independent macrophage cell death and host colonizationThe Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responsesAutophagy, Inflammation, and Metabolism (AIM) Center in its second yearCorrection: Mitochondrial DNA synthesis fuels NLRP3 inflammasomeDimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasomeInflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in miceMitochondrial DNA synthesis fuels NLRP3 inflammasomeNoncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular trapsInterleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretionHepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genesAutophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborationsMCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis miceCutting edge: blockade of inhibitor of apoptosis proteins sensitizes neutrophils to TNF- but not lipopolysaccharide-mediated cell death and IL-1β secretionIFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infectionCaspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activityMultiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitisMechanisms and Consequences of Inflammasome ActivationZebrafish earns its stripes for in vivo ASC speck dynamicsSulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitorsIn life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosisXIAP loss triggers RIPK3- and caspase-8-driven IL-1β activation and cell death as a consequence of TLR-MyD88-induced cIAP1-TRAF2 degradationNLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in miceActive MLKL triggers the NLRP3 inflammasome in a cell intrinsic mannerRole of NLRP3 inflammasome in a model of acute burn-induced painSalmonella-induced inflammasome activation in humansK+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondriaIL-1 contributes to the anti-cancer efficacy of ingenol mebutateQuestions and Controversies in innate immune research: What is the physiological role of NLRP3?Familial auto inflammation with neutrophilic dermatosis reveals a novel regulatory mechanism of pyrin activationSterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signalsSalmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophagesThe murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonistsNLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signallingStrain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expressionThe inflammasome adaptor ASC induces procaspase-8 death effector domain filamentsNLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunityMechanisms of unconventional secretion of IL-1 family cytokinesMetabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signalingDeficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseasesA novel flow cytometric method to assess inflammasome formationBurn the house, save the day: pyroptosis in pathogen restrictionSphingomyelin phosphodiesterase Acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophagesThe Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella ChallengeRab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signallingAIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASCPattern recognition receptor function in neutrophilsAn antioxidant role for catecholate siderophores in SalmonellaHistone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophagesInnate immunity, the constant gardener of antimicrobial defenseThe structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidizedAcute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor inductionThe mammalian PYHIN gene family: Phylogeny, evolution and expressionNovel insights into the innate immune response to non-tuberculous MycobacteriaConservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophagesNLRC5 deficiency selectively impairs MHC class idependent lymphocyte killing by cytotoxic T cellsThe death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascadeDifferential expression of NLRP3 among hematopoietic cellsMacrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesisUpdate of the FANTOM web resource: From mammalian transcriptional landscape to its dynamic regulationPhosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretionThe combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cellsDifferential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPSNLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?The NLRP3 inflammasome: a sensor for metabolic danger?DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κBThe regulated retrotransposon transcriptome of mammalian cellsThe transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell lineTiny RNAs associated with transcription start sites in animalsData-driven normalization strategies for high-throughput quantitative RT-PCRInnate immunity: Cytoplasmic DNA sensing by the AIM2 inflammasomeColony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophagesA rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGEDevelopment of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencerThe macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicansOsteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and In VivoExpression analysis of G Protein-coupled receptors in mouse macrophagesDifferential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophagesG-protein-coupled receptor expression, function, and signaling in macrophagesPU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophagesHistone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitmentAlternate transcription of the Toll-like receptor signaling cascadeLPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expressionSignal integration between IFN gamma and TLR signalling pathways in macrophagesLPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 actionInterferon-gamma: an overview of signals, mechanisms and functionsProbing the S100 protein family through genomic and functional analysisActivity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitorsXIAP deficiency results in excess NLRP3 inflammasome activation and cell death as a consequence of TLR-MyD88 induced cIAP1-TRAF2 degradationMolecular arrangement and activation of procaspases-1 and-8 at inflammasomesA novel approach to investigate the assembly of the NOD-like receptor inflammasomesExploring NLRP12-An emerging member of NOD-like receptor familyMCC950 is a potent and specific inhibitor of the NLRP3 inflammasome and a novel potential therapeutic for NLRP3 driven diseasesFunctional significance of evolutionary divergence in Toll-like receptor-regulated gene expression in human versus mouseNLRC5 deficiency impairs MHC class I-dependent lymphocyte killing by cytotoxic T cellsExpression and function of Schlafen-4 in macrophage biology and inflammationPrimary murine osteoblast cultures contain macrophages that enhance osteoblast mineralisationPrimary murine osteoblast cultures contain macrophages that enhance osteoblast mineralizationPrimary Murine Osteoblast Cultures Contain Macrophages that Enhance Osteoblast MineralisationPU.1 and ICSBP regulate the tlr9 promoter in mouse macrophagesSulfonylureas and related compounds and use of the sameSulfonylureas and related compounds and use of the sameMechanisms of IFN[gamma] priming of macrophage activation by CpG DNA
(2005). (2016). Zamoshnikova, Alina, Gross, Christina J., Vasquez, Flor, Schuster, Steffen, Tacchini-Cottier, Fabienne, Richards, Ayanthi and Schroder, Kate (2014). Burgener, Sabrina Sofia and Schroder, Kate (2020). (2015). Perera, Agampodi Promoda, Fernando, Ruchira, Shinde, Tanvi, Gundamaraju, Rohit, Southam, Benjamin, Sohal, Sukhwinder Singh, Robertson, Avril A. Coll, Rebecca C., Holley, Caroline L. and Schroder, Kate (2018). (2017). (2015). Join us for the opportunity to listen to ARC Future Fellow and Head of the Inflammasome Laboratory at IMB Associate Professor Kate Schroder.
Westland Ford Dealer, Anthony Welsh Top Boy, Sta Wealth Management Fees, The Police - Tea In The Sahara (live), Ke Lingling London, Pat Tillman Cause Of Death, Ahilya Store Bandra, Breckenridge Brewery Events, Cardinal Egan Residence, Ripping Yarns Hopping Race, Shanghai Blues (1984), Contact Number List, How Old Is Sandra Crouch, Revillagigedo Islands Population, Erebos Book Wikipedia, Nine And Three Quarters Meaning, Velia Name Pronunciation, Old Peru Currency, Second Manassas Campaign, Sony Ten 1 Live Streaming Link, Jeannie Berlin Succession, Josh Adam Celtic, Williams Vs Ahrens, MLB Players 2019, Michael Parsa Age, Lil Pump Lyrics Generator, Tracy Ifeachor Husband,